Project Description

Author: et al.

Summary:

Introduction: Bangladesh has experienced a large scale epidemic of dengue in 2019 affecting both children and adults. The objective of the present study was to compare e the clinical and laboratory parameters of pediatric and adult dengue cases during this epidemic.

Methods: The retrospective study comprises data of 739 confirmed pediatric cases collected from the Dhaka Sishu Hospital and 486 adult confirmed dengue cases from the Dhaka Medical College Hospital. The study period was between June to September 2019. Clinical and laboratory information were retrieved along with sociodemographic data.

Results: The average age of the pediatric and adult cases was 6.6 (SD 4.7) and 30 (SD 11.5) years, respectively and almost 60% were male. Around 10% of the pediatric and 16.7% of the adult patients developed severe dengue. Fever (89%), nausea/vomiting (56%), diarrhea (18%), headache (28%) and retro-orbital pain (18%) were the most common conventional clinical presentation. Abdominal pain (29%), persistent vomiting (7.6%) and mucosal bleeding (14%) were most commonly presented warning signs. Evidence of clinical fluid accumulation and dengue shock syndrome were present in almost 5.9 and 6.4% of patients respectively. Thrombocytopenia and leukopenia were present in 32 and 28% of the patients while raised serum ALT and/or AST was present in 23% and 39% patients respectively. Presence of warning signs (aOR 5.10, 95% CI 2.24-11.61, p-value <0.001 for children and aOR 12.47, 95% CI 5.51-28.21, p-value <0.001) and raised ALT (aOR 2.13, 95% CI 1.15-3.97, p-value 0.022 for children and aOR 2.19, 95% CI 1.05-4.60, p-value 0.037) were independent risk factors for severe dengue.

Conclusion: Adult patients more commonly developed severe dengue compared to pediatric patients.

Keywords: Dengue, Pediatric patients, Adult patients, Epidemic, Severe dengue

Status: Ongoing

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