Project Description

Author: Chowdhury et al.


Viral hepatitis due to hepatitis B virus and C virus (HCV) is a major contributor to the huge burden of chronic liver disease in Bangladesh. The present study aimed to investigate the sero-prevalence of HCV among decompensated CLD patients admitted to Sylhet M.A.G. Osmani Medical College Hospital (SOMCH). This cross-sectional study was conducted among 58 admitted patients with SOMCH aged ≥ 18 years with a diagnosis of decompensated CLD. Detailed clinical data were extracted from the hospital records and physical examination. The immunochromatographic direct binding method was used for detection of Anti-HCV antibody. The mean age of the patients was 45.7 (SD 13.3) years, and 86% of them were male. Seropositivity of anti-HCV antibody was 17.2%, with a predominance of genotype-3. Around 58% patients had CLD class C in the Child-Pugh scoring system. Edema (91%), testicular atrophy (81%), leukonychia (72%), jaundice (58%), clubbing (58%), palmar erythema (50%), flapping tremor (43%) and ascites (40%) were the most common presentations of the patients. HCV infection contributed to almost one-fifth of decompensated CLD in hospital-admitted patients. Mass screening and adequate preventive measures are recommended to mitigate the burden of HCV-induced CLD.

Status: Ongoing

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