Project Description

Author: Selim et al.


Introduction: Thyroid disorders are common in pregnancy and are associated with adverse pregnancy outcomes. The objective of the present study was to assess thyroid status and its association with adverse maternal and neonatal outcomes in pregnant women in Bangladesh.

This cross-sectional study was conducted on 252 women with term pregnancy included from the Department of Gynecology and Obstetrics of Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital from September 2019 to October 2020. Their sociodemographic, clinical, and pregnancy-related data were collected by interview and physical examination, and their thyroid function test was carried out afterwards to determine the prevalence of thyroid disorders.

The mean FT4 and TSH levels in the pregnant women were 0.96 (SD 0.1) ng/dL and 1.8 (SD 1.6) mIU/ml, respectively. The prevalence of overt hypothyroidism was 3.2%, and subclinical hypothyroidism was 5.2%. None of the pregnant women were diagnosed with overt or subclinical hyperthyroidism. A total of 13% of women were positive for anti-thyroid antibodies. Adverse maternal and fetal outcomes, such as postpartum hemorrhage, low birth weight, intrauterine growth retardation and neonatal hypothyroidism, were more prevalent among women with overt or subclinical hypothyroidism (p value <0.001).

Conclusion: A substantial number of pregnant women in Bangladesh suffer from subclinical or overt hypothyroidism, which increases their risk of adverse pregnancy outcomes.

Status: Ongoing

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