Immunogenicity and safety of two WHO approved post-exposure rabies vaccine intradermal (ID) regimens: the 4-site one-month compared with the 2-site one week regimen- An open-label head-to-head randomized clinical trial
Author: Basher et al. Summary: Status: Ongoing Full text link: Not available
Clinical Trial report for our Anti-diabetic product Omari
Author: et al. Summary: This comprehensive review explores the intricate relationship between diabetes and inflammation. Diabetes, particularly type 2 diabetes, is characterized by chronic inflammation, and inflammation, in turn, exacerbates insulin resistance and diabetes-related complications. This article discusses the underlying mechanism and link between diabetes and inflammation, including the role of adipose tissue, immune responses, and inflammatory signaling pathways. Furthermore, it examines the impact of inflammation on insulin resistance, pancreatic beta cell dysfunction, and the development of complications of diabetes. Additionally, the review highlights various management strategies targeting inflammation in patients with diabetes, focusing the lifestyle modifications, dietary interventions, physical
Quality of life of confirmed hemophilia cases registered in the hemophilia treatment center, Rajshahi, Bangladesh
Author: Morsed et al. Summary: Hemophilia, one of the most common inherited bleeding disorders characterized by deficiencies of clotting factors VIII and IX results in frequent and spontaneous bleeding.1 The classic form termed as hemophilia A, is caused by deficiency of factor VIII, while hemophilia B or Christmas disease is caused by deficiency of factor IX.2 Both of these diseases shared a classic X-linked pattern of inheritance, which results from the deficiency of a coagulation factor. As a result, both of the type of hemophilia affect predominantly males and females becoming carriers of the conditions.1 Acquired hemophilia is a separate
Efficacy and Safety of Tirzepatide in Type 2 Diabetes Mellitus and Obesity Management: A Real Word Evidence
Title: Efficacy and Safety of Tirzepatide in Type 2 Diabetes Mellitus and Obesity Management: A Real Word Evidence Author: Selim et al. Summary: The concurrent presence of type 2 diabetes mellitus (T2DM) and obesity represents a significant public health challenge, due to subsequent burden of multiple morbidities and associated mortality. Tirzepatide, a dual Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) receptor which is a once-weekly injectable medication, has been demonstrated as a promising therapeutic strategy to combat both of these conditions in certain clinical trials. The present study aims to assess the real-world effectiveness and safety of tirzepatide in
Efficacy and Safety of Omarigliptin, A Weekly Dipeptidyl Peptidase-4 Inhibitor for Type 2 Diabetes Management: Real-World Evaluation in Bangladesh
Author: Amin et al. Summary: The escalating global prevalence of type 2 diabetes mellitus (T2DM) with its associated healthcare burden necessitate the innovation of effective and adaptable treatment approaches. Omarigliptin, a once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, has been demonstrated with promising outcomes in the management of T2DM in clinical trials conducted across the world. This study aims to assess the real-world effectiveness and safety of omarigliptin in the management of newly diagnosed T2DM clinical settings in Bangladesh. This observational study will be conducted at BIRDEM General Hospital in Bangladesh over a period of 12 months. Individuals aged 18 years or
Safety and efficacy of Mesenchymal stem cell for the treatment of acute burn patients: a single-center open label randomized clinical trial
Author: Ali et al. Summary: Nowadays, the application of stem cell therapy is at the forefront of regenerative medicine. However, the current approach for burn injury treatment using autologous skin graft often results in significant morbidities including hypertrophied scarring, wound contracture, graft rejection, and chronic wound infection. Additionally, this approach does not cover burn injuries of any magnitude or location. Therefore, stem cell therapy to promote tissue regeneration in burn victims heralds a new era in skin damage and burn injury treatment. Thus, this trial aims to compare the safety and efficacy of mesenchymal stem cell therapy (bone marrow-derived and
Intravenous iron sucrose vs. blood transfusion in the management of moderate postpartum iron deficiency anemia: A non-randomized quasi-experimental study
Author: Rehana et al. Summary: Postpartum anemia is often over-treated with blood transfusion without clear indication despite having a potential alternative of parenteral iron therapy. The present study aimed to compare the efficacy of intravenous (IV) iron sucrose with blood transfusion in increasing the hematological parameters in postpartum women with moderate anemia. This prospective non-randomized quasi-experimental study was conducted among 44 hemodynamically stable postpartum women with moderate anemia (Hb 7–8 g/dl) in the Obstetrics department of Dhaka Medical College Hospital (DMCH) from January to June 2021. Among them, 22 patients received 600 mg of IV iron sucrose after 48 h
Effect of telmisartan and vitamin E on liver histopathology with non‐alcoholic steatohepatitis: A randomized, open‐label, noninferiority trial
Author: Alam et al. Summary: To compare the effect of telmisartan and vitamin E on liver histopathology of non-alcoholic steatohepatitis (NASH) patients. This noninferiority clinical trial was conducted for 1 year. Fatty liver patients with non-alcoholic fatty liver disease (NAFLD) activity score (NAS) ≥ 5 (in liver biopsy) were selected. All methods were in accordance with the Declaration of Helsinki. Patients who received telmisartan and vitamin E were denoted as Group-T and Group-E, respectively. Forty patients >18 years old were assigned and divided into two groups (20 in each group). Histological improvements were primary outcome measures. Significant improvement in NAS
Open Label Randomized Controlled Comparison of Three Alternative Regimes of Ciprofloxacin, Azithromycin and Cefixime for Treatment of Uncomplicated Typhoid Fever in Bangladesh
Author: Amin et al. Summary: Multi-drug resistant Typhoid fever (resistant to previously used chloramphenicol, ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole) has been commonly described in the South East Asia region and a recent report suggests that the salmonella typhi have reduced response to fluoroquinolones (nalidixic acid-resistant). The optimum treatment protocol for this type of serovar has not been established. This study compared different antimicrobial regimens for the treatment of uncomplicated typhoid fever which was conducted in the medicine ward of Dhaka Medical College Hospital (DMCH) and outdoor setting in private practice in Dhaka metropolitan city, Mymensingh and Sylhet town from January 2017
Virucidal Effect of Povidone Iodine on SARS-CoV-2 in Nasopharynx: An Open-label Randomized Clinical Trial
Author: Arefin et al. Summary: Povidone-iodine (PVP-I) is a time-tested antiseptic agent with excellent virucidal (99.99%) properties. Repurposing it against coronavirus disease-19 (COVID-19) is a relatively newer concept and has been sparsely tested in vivo. The most common route of entry of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is the nasopharynx. Averting colonization of the virus could be one of the best options to reduce the incidence of infection. PVP-I gargle and mouthwash were found to be effective in vitro rapid inactivation against SARS-CoV-2 on a smaller scale (Hassandarvish et al. in BDJ 1-4, 2020, Pelletier et al.