Project Description

Author: Anjuman et al.

Summary:

Whipple’s procedure or Pancreaticoduodenectomy is a frightening surgery and was associated with high morbidity and mortality. Outcome statistics of this procedure are not readily available in our country context. Therefore, this study was designed to delineate the outcome of the patients who underwent Whipple’s Procedure in a tertiary care setting.

This retrospective study included all patients admitted and underwent Whipple’s procedure at department of surgery in Sir Salimullah medical college and Mitford hospital, Dhaka from January 2017 to May 2020. Total 5 follow up: immediate post-operative, at moths 1, 6, 12 and 18 months were recorded. Data was retrieved from hospital discharge records. The survival status for all patients was obtained by using a pre-formed questionnaire. Post-operative survival status was assessed using a Kaplan-Meier curve. Analysis was done by SPSS 26.

A total of 19 patients were included with mean age 50.84±12.97 (SD) years. Male and females constituted 57.9 and 42.1% of the patients. All had a malignant etiology with periampullary carcinoma being the commonest (68.4%). The 6-months and 12-month mortality for patients undergoing Whipple’s procedure was 5.3% and 23.5%, respectively. Kaplan Meier survival analysis showed that the probability of surviving after 18 months was approximately 80%. A comparison of survival across sex, diagnosis and tumor grade revealed non-significant difference (p= 0.066, 0.895 and 0.240 respectively).

Conclusion: In this retrospective cohort it was found that nearly three-fourth patients survived one-year after Whipple’s procedure and the eighteen months survival probability was approximately eighty percent. However, further larger cohort study is required to provide a more precise picture.

Keywords: Whipple’s Procedure, Pancreaticoduodenectomy, Follow-up studies, Pancreatic surgery

Status: Ongoing

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